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KMID : 0350519920450020735
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Journal of Catholic Medical College
1992 Volume.45 No. 2 p.735 ~ p.745
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Mucin Histochemistry of Gastric Carcinoma and Adjacent Mucosa Induced by Oral Administration of N-Methyl-N'-nitro-N-nitrosoguanidine in Rats
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Abstract
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There have been as few histochemical studies of the epithelial mucins observed in chronic gastritis and gastric carcinoma, and of the types of mucin present in the cells of normal and pathologic epithelium. Since more refined methods have been
develped
recently for the detection and differentiation of polysaccharides, and attempt to-indntify the cell of origin of the neutral and acid components of the gastric juice was deemed profitable. The association of intestinal metaplasia in atrophic
gastritis
and gastric carcinoma has been known for many years. Mucosubstances in metaplastic gastric mucosa are more acidic than normal mucosa, especially metaplastic mucosa adjacent to carcinoma. And it appeared that although most gastric carcinomas
contained
acid mucins in their cytoplasm, they varied considerably in their content of the sulfated and nonsulfated forms, even within the same carcinoma. To evaluate the various mucins in the epithelium of gastric carcinoma and adjacent gastric mucosa,
authors
induced 19 gastric carcinomas in 73 rats experimentally bo oral administtration of N-Methyl-N'-nitro-N-nitroguanidine(MNNG). During experiment the incidence of gastric carcinoma in each group was from 14.3% to 42.9%, and 4 were poorly
differentiated
adenocarcinoma and 15 were well and moderately differentiated tubular adenocarcinoma. There was no cancer in the cotrol group. In the adjacent mucosa, there were areas of intestinal metaplasia with varying degree, and neutral and acid mucins were
increased in the metaplastic mucosa. There was a tendency of increase in sulfur mucin than sialomucin in the adjacent mucosa after 50 week group. Neoplastic cells also contained both neutral and acid mucins, and they varied considerably in the
contents
of mucins even within the same carcinoma. But in all the carcinoma during the experiment, sialomucin was more predominant than sulfurmucin in poorly differentiated adenocarcinoma and in well and moderately differentiated tubular carcinoma. It
seemed
that no correlation was possible between the mucin reactions of the carcinoma and those of the adjacent gastric mucosa.
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KEYWORD
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